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Therapy Name | Durvalumab + MEDI5083 |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Durvalumab | Imfinzi | MEDI4736 | Immune Checkpoint Inhibitor 146 PD-L1/PD-1 antibody 86 | Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA approved for use in patients with urothelial carcinoma and unresectable, stage III non-small cell lung cancer, and in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer (FDA.gov). |
MEDI5083 | MEDI 5083|MEDI-5083 | MEDI5083 is a fusion protein consisting of CD40LG (CD40L) ligand and an immunoglobulin (Ig) Fc fragment, which activates TNFRSF5 (CD40) to stimulate proliferation of T-cells and enhance an anti-tumor response (AACR; Cancer Res 2018;78(13 Suppl):Abstract nr CT126). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT03089645 | Phase I | MEDI5083 Durvalumab + MEDI5083 | MEDI5083 Alone and in Combination With Durvalumab in Subjects With Select Advanced Solid Tumors | Completed | USA | 1 |