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Therapy Name MEDI5083
Synonyms
Therapy Description

MEDI5083 is a fusion protein consisting of CD40LG (CD40L) ligand and an immunoglobulin (Ig) Fc fragment, which activates TNFRSF5 (CD40) to stimulate proliferation of T-cells and enhance an anti-tumor response (AACR; Cancer Res 2018;78(13 Suppl):Abstract nr CT126).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MEDI5083 MEDI 5083|MEDI-5083 MEDI5083 is a fusion protein consisting of CD40LG (CD40L) ligand and an immunoglobulin (Ig) Fc fragment, which activates TNFRSF5 (CD40) to stimulate proliferation of T-cells and enhance an anti-tumor response (AACR; Cancer Res 2018;78(13 Suppl):Abstract nr CT126).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03089645 Phase I MEDI5083 Durvalumab + MEDI5083 MEDI5083 Alone and in Combination With Durvalumab in Subjects With Select Advanced Solid Tumors Completed USA 1


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