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|Therapy Name||DC AML Vaccine + Durvalumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|DC AML Vaccine||DC AML vaccine is generated by fusing patient derived AML cells with autologous dendritic cells, resulting in anti-tumor immune response (PMID: 25625926, Blood 2013 122:3928).|
|Durvalumab||Imfinzi||MEDI4736||Immune Checkpoint Inhibitor 98 PD-L1/PD-1 antibody 67||Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA approved for use in patients with urothelial carcinoma and unresectable, stage III non-small cell lung cancer, and in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03059485||Phase II||DC AML Vaccine DC AML Vaccine + Durvalumab||DC/AML Fusion Cell Vaccine vs DC/AML Fusion Cell Vaccine Plus Durvalumab vs Observation in Patients Who Achieve a Chemotherapy-induced Remission||Recruiting||USA||0|