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|Therapy Name||AZD8701 + Durvalumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AZD8701||AZD-8701|AZD 8701||Antisense Therapy 12||AZD8701 is an antisense oligonucleotide that targets FOXP3 and modulates expression of its target genes, which potentially results in reduced immunosuppession (Cancer Res 2019;79(13 Suppl):Abstract nr 2713).|
|Durvalumab||Imfinzi||MEDI4736||Immune Checkpoint Inhibitor 148 PD-L1/PD-1 antibody 93||Imfinzi (durvalumab) is a monoclonal antibody that binds to and inhibits PD-L1 (CD274), potentially resulting in increased immune response to tumors (PMID: 25943534, PMID: 28214651). Imfinzi (durvalumab) is FDA approved for use in patients with urothelial carcinoma and unresectable, stage III non-small cell lung cancer, in combination with etoposide and carboplatin or cisplatin in patients with extensive stage small cell lung cancer, and in combination with cisplatin and gemcitabine in patients with locally advanced or metastatic biliary tract cancer (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04504669||Phase I||AZD8701 + Durvalumab AZD8701||First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours||Recruiting||USA | FRA | ESP | CAN||0|