Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name AVB-S6-500
Trade Name
Synonyms AVBS6500|AV S6 500|Batiraxcept|AVB-500|RUGA-S6
Drug Descriptions

AVB-S6-500 is a fusion protein comprised of human IgG1 linked to the extracellular domain of Axl, which binds to growth arrest-specific protein 6 (GAS6), potentially resulting in decreased downstream signaling and reduced tumor growth (PMID: 32148495, PMID: 31599479).

CAS Registry Number 2268717-61-7
NCIT ID C156017


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
AVB-S6-500 AVB-S6-500 0 1
AVB-S6-500 + Avelumab AVB-S6-500 Avelumab 0 1
AVB-S6-500 + Cabozantinib AVB-S6-500 Cabozantinib 0 1
AVB-S6-500 + Carboplatin AVB-S6-500 Carboplatin 0 0
AVB-S6-500 + Carboplatin + Paclitaxel AVB-S6-500 Carboplatin Paclitaxel 0 1
AVB-S6-500 + Durvalumab AVB-S6-500 Durvalumab 0 1
AVB-S6-500 + Gemcitabine + Nab-paclitaxel AVB-S6-500 Gemcitabine Nab-paclitaxel 0 1
AVB-S6-500 + Paclitaxel AVB-S6-500 Paclitaxel 0 3
AVB-S6-500 + Pegylated liposomal doxorubicin AVB-S6-500 Pegylated liposomal doxorubicin 0 1

Additional content available in CKB BOOST