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Drug Name AVB-S6-500
Trade Name
Synonyms AVBS6500|AV S6 500
Drug Descriptions

AVB-S6-500 is a fusion protein comprised of human IgG1 linked to the extracellular domain of Axl, which binds to growth arrest-specific protein 6 (GAS6), potentially resulting in decreased downstream signaling and reduced tumor growth (PMID: 32148495, PMID: 31599479).

CAS Registry Number NA
NCIT ID C156017


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AVB-S6-500 AVB-S6-500 0 0
AVB-S6-500 + Avelumab AVB-S6-500 Avelumab 0 1
AVB-S6-500 + Cabozantinib AVB-S6-500 Cabozantinib 0 1
AVB-S6-500 + Carboplatin AVB-S6-500 Carboplatin 0 0
AVB-S6-500 + Carboplatin + Paclitaxel AVB-S6-500 Carboplatin Paclitaxel 0 1
AVB-S6-500 + Durvalumab AVB-S6-500 Durvalumab 0 1
AVB-S6-500 + Gemcitabine + Nab-paclitaxel AVB-S6-500 Gemcitabine Nab-paclitaxel 0 1
AVB-S6-500 + Paclitaxel AVB-S6-500 Paclitaxel 0 2
AVB-S6-500 + Pegylated liposomal-doxorubicin AVB-S6-500 Pegylated liposomal-doxorubicin 0 1

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