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Drug Name ADI-PEG 20
Trade Name
Synonyms Pegargiminase|ADI-PEG20
Drug Descriptions

Pegargiminase (ADI-PEG 20) is polyethylene glycol-conjugated arginine deiminase which degrades arginine, thereby depleting arginine and potentially inhibiting growth of arginine-dependent tumor cells (PMID: 22864522, PMID: 30796035, PMID: 32409304).

CAS Registry Number 1394129-74-8
NCIT ID C91702


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ADI-PEG 20 ADI-PEG 20 0 1
ADI-PEG 20 + Cisplatin + Pemetrexed Disodium ADI-PEG 20 Cisplatin Pemetrexed Disodium 0 1
ADI-PEG 20 + Docetaxel + Gemcitabine ADI-PEG 20 Docetaxel Gemcitabine 0 1
ADI-PEG 20 + Ipilimumab + Nivolumab ADI-PEG 20 Ipilimumab Nivolumab 0 1

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