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|Therapy Name||BMS-986178 + Ipilimumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|BMS-986178||BMS986178|BMS 986178||OX40 Antibody 10||BMS-986178 is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (PMID: 33148673).|
|Ipilimumab||Yervoy||BMS-734016||CTLA4 Antibody 18 Immune Checkpoint Inhibitor 98||Yervoy (ipilimumab) is an antibody that binds to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), causing increased T-cell activation (PMID: 28891423). Yervoy (ipilimumab) is FDA approved for use in patients with metastatic melanoma, including patients 12 years or older, and in combination with Opdivo (nivolumab) for intermediate or poor-risk renal cell carcinoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (including patients 12 years or older), hepatocellular carcinoma previously treated with Nexavar (sorafenib), in combination with Opdivo (nivolumab) as first-line therapy in patients with PD-L1-positive (>=1%) metastatic non-small cell lung cancer without EGFR or ALK alterations, and in combination with Opdivo (nivolumab) and platinum-based chemotherapy as first-line therapy in patients with metastatic or recurrent non-small cell lung cancer without EGFR or ALK alterations (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||Advanced Solid Tumor||no benefit||BMS-986178 + Ipilimumab||Phase Ib/II||Actionable||In Phase I/II trial, BMS-986178 and Yervoy (ipilimumab) combination therapy demonstrated manageable safety profile, resulted in an objective response rate of 0% (0/34; 0/6) in different cohorts of patients with advanced solid tumors (PMID: 33148673; NCT02737475).||33148673|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|