Drug Detail


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Drug Name BMS-986205
Trade Name
Synonyms BMS986205|BMS 986205|ONO-7701|Linrodostat
Drug Descriptions

BMS-986205 (Linrodostat) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 29167110, PMID: 31823654).

DrugClasses IDO1 Inhibitor 12 Immune Checkpoint Inhibitor 151
CAS Registry Number 1923833-60-6
NCIT ID C141135


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Therapy Name Drugs Efficacy Evidence Clinical Trials
BCG solution + BMS-986205 + Nivolumab BCG solution BMS-986205 Nivolumab 0 1
BMS-986205 BMS-986205 0 0
BMS-986205 + Cisplatin + Gemcitabine + Nivolumab BMS-986205 Cisplatin Gemcitabine Nivolumab 0 1
BMS-986205 + Ipilimumab + Nivolumab BMS-986205 Ipilimumab Nivolumab 0 1
BMS-986205 + Nivolumab BMS-986205 Nivolumab 0 12
BMS-986205 + Nivolumab + Relatlimab BMS-986205 Nivolumab Relatlimab 0 1
BMS-986205 + Nivolumab + Temozolomide BMS-986205 Nivolumab Temozolomide 0 1

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