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Drug Name | BMS-986205 |
Trade Name | |
Synonyms | BMS986205|BMS 986205|ONO-7701|Linrodostat |
Drug Descriptions |
BMS-986205 (Linrodostat) inhibits indoleamine 2,3-dioxygenase 1 (IDO1) to prevent tryptophan breakdown in the tumor microenvironment, thereby activating a cytotoxic immune response against IDO1 expressing tumor cells (PMID: 29167110, PMID: 31823654). |
DrugClasses | IDO1 Inhibitor 12 Immune Checkpoint Inhibitor 151 |
CAS Registry Number | 1923833-60-6 |
NCIT ID | C141135 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
BCG solution + BMS-986205 + Nivolumab | BCG solution BMS-986205 Nivolumab | 0 | 1 |
BMS-986205 | BMS-986205 | 0 | 0 |
BMS-986205 + Cisplatin + Gemcitabine + Nivolumab | BMS-986205 Cisplatin Gemcitabine Nivolumab | 0 | 1 |
BMS-986205 + Ipilimumab + Nivolumab | BMS-986205 Ipilimumab Nivolumab | 0 | 1 |
BMS-986205 + Nivolumab | BMS-986205 Nivolumab | 0 | 12 |
BMS-986205 + Nivolumab + Relatlimab | BMS-986205 Nivolumab Relatlimab | 0 | 1 |
BMS-986205 + Nivolumab + Temozolomide | BMS-986205 Nivolumab Temozolomide | 0 | 1 |