Drug Detail


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Drug Name Linrodostat
Trade Name
Synonyms BMS986205|BMS 986205|ONO-7701|BMS-986205
Drug Descriptions

Linrodostat (BMS-986205) inhibits indoleamine 2,3-dioxygenase 1 (IDO1), which results in decreased breakdown of tryptophan into kynurenine in the tumor microenvironment, potentially resulting in enhanced anti-tumor immune response (PMID: 31823654, PMID: 33298590).

DrugClasses IDO1 Inhibitor 12
CAS Registry Number 1923833-60-6
NCIT ID C141135


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Therapy Name Drugs Efficacy Evidence Clinical Trials
BCG solution + Linrodostat + Nivolumab BCG solution Linrodostat Nivolumab 0 1
Cisplatin + Gemcitabine + Linrodostat + Nivolumab Cisplatin Gemcitabine Linrodostat Nivolumab 0 1
Ipilimumab + Linrodostat + Nivolumab Ipilimumab Linrodostat Nivolumab 0 1
Linrodostat Linrodostat 0 0
Linrodostat + Nivolumab Linrodostat Nivolumab 0 12
Linrodostat + Nivolumab + Relatlimab Linrodostat Nivolumab Relatlimab 0 1
Linrodostat + Nivolumab + Temozolomide Linrodostat Nivolumab Temozolomide 0 1

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