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Therapy Name Ipilimumab + Sargramostim + UV1 Telomerase peptide vaccine
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Ipilimumab Yervoy BMS-734016 CTLA4 Antibody 17 Immune Checkpoint Inhibitor 94 Yervoy (ipilimumab) is an antibody that binds to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), causing increased T-cell activation (PMID: 28891423). Yervoy (ipilimumab) is FDA approved for use in patients with metastatic melanoma, including patients 12 years or older, and in combination with Opdivo (nivolumab) for intermediate or poor-risk renal cell carcinoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (including patients 12 years or older), hepatocellular carcinoma previously treated with Nexavar (sorafenib), in combination with Opdivo (nivolumab) as first-line therapy in patients with PD-L1-positive (>=1%) metastatic non-small cell lung cancer without EGFR or ALK alterations, and in combination with Opdivo (nivolumab) and platinum-based chemotherapy as first-line therapy in patients with metastatic or recurrent non-small cell lung cancer without EGFR or ALK alterations (FDA.gov).
Sargramostim Leukine GM-CSF|Prokine
UV1 Telomerase peptide vaccine UV1/hTERT Peptide Vaccine UV1 Telomerase peptide vaccine consists of three human Telomerase (hTERT) epitopes derived from the wild-type protein, which potentially induces anti-tumor immune response (Annals of Oncology, Vol. 27, Suppl. 8, VIII11, 2016; Abs nr: 36P, PMID: 28391357).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown melanoma not applicable Ipilimumab + Sargramostim + UV1 Telomerase peptide vaccine Phase I Actionable In a Phase I/IIa trial, UV1 Telomerase peptide vaccine combined with Yervoy (ipilimumab) and Sargramostim was well-tolerated, and resulted in a complete response and three partial responses (n=12) in metastatic melanoma patients, with a three-year overall survival of 67% (Journal of Clinical Oncology 2020 38:5_suppl, 62-62; NCT02275416). detail...

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Clinical Trial Phase Therapies Title Recruitment Status


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