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Drug Name CBL0137
Trade Name
Synonyms CBL 0137|CBL-0137
Drug Descriptions

CBL0137 is a curaxin compound that binds to and inhibits the facilitates chromatin transcription (FACT) complex, resulting in apoptosis in cancer cells (PMID: 25402820) and also disrupts DNA and histone interactions (PMID: 30926878, PMID: 32631516, PMID: 32202904).

CAS Registry Number 1197996-80-7
NCIT ID C107239


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Therapy Name Drugs Efficacy Evidence Clinical Trials
CBL0137 CBL0137 0 4
CBL0137 + Gemcitabine CBL0137 Gemcitabine 0 0
CBL0137 + Ipilimumab + Nivolumab CBL0137 Ipilimumab Nivolumab 0 1

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