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|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|CBL0137||CBL0137 is a curaxin compound that binds to and inhibits the facilitates chromatin transcription (FACT) complex, resulting in apoptosis in cancer cells (PMID: 25402820) and also disrupts DNA and histone interactions (PMID: 30926878).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT01905228||Phase I||CBL0137||A Phase 1 Trial of CBL0137 in Patients With Metastatic or Unresectable Advanced Solid Neoplasm or Refractory Lymphomas||Completed|
|NCT03727789||Phase I||CBL0137||CBL0137 in Treating Patients With Advanced Extremity Melanoma or Sarcoma||Recruiting|
|NCT02931110||Phase I||CBL0137||Study of IV CBL0137 in Previously Treated Hematological Subjects||Suspended|