Missing content? – Request curation!
Request curation for specific Genes, variants, or PubMed publications.
Have questions, comments or suggestions? - Let us know!
Email us at : firstname.lastname@example.org
|Therapy Name||Ipilimumab + PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Ipilimumab||Yervoy||BMS-734016||CTLA4 Antibody 16 Immune Checkpoint Inhibitor 94||Yervoy (ipilimumab) is an antibody that binds to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), causing increased T-cell activation (PMID: 28891423). Yervoy (ipilimumab) is FDA approved for use in patients with metastatic melanoma, including patients 12 years or older, and in combination with Opdivo (nivolumab) for intermediate or poor-risk renal cell carcinoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (including patients 12 years or older), hepatocellular carcinoma previously treated with Nexavar (sorafenib), in combination with Opdivo (nivolumab) as first-line therapy in patients with PD-L1-positive (>=1%) metastatic non-small cell lung cancer without EGFR or ALK alterations, and in combination with Opdivo (nivolumab) and platinum-based chemotherapy as first-line therapy in patients with metastatic or recurrent non-small cell lung cancer without EGFR or ALK alterations (FDA.gov).|
|PROSTVAC-F/TRICOM||PROSTVAC-F/TRICOM is a cancer vaccine consisting of a recombinant fowlpox virus encoding PSA and TRICOM (a combination of B7.1, ICAM-1, and LFA-3), which induces antitumor immune response against PSA-positive tumors (PMID: 16390546).|
|PROSTVAC-V/TRICOM||PROSTVAC-V/TRICOM is a cancer vaccine consisting of a recombinant vaccinia virus encoding PSA and TRICOM (a combination of B7.1, ICAM-1, and LFA-3) which induces antitumor immune response against PSA-positive tumors (PMID: 16390546).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02506114||Phase II||PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM Ipilimumab Ipilimumab + PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM||Neoadjuvant PROSTVAC-VF With or Without Ipilimumab for Prostate Cancer||Terminated|
|NCT02933255||Phase Ib/II||Ipilimumab + PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM Ipilimumab + Nivolumab + PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM Nivolumab + PROSTVAC-F/TRICOM + PROSTVAC-V/TRICOM||PROSTVAC in Combination With Nivolumab and/or Ipilimumab in Men With Prostate Cancer||Recruiting|