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|Therapy Name||CPI-1205 + Ipilimumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|CPI-1205||EZH2 inhibitor 19||CPI-1205 inhibits EZH2, including both wild-type and mutant forms, potentially resulting in decreased tumor growth (PMID: 27739677, PMID: 29905573).|
|Ipilimumab||Yervoy||BMS-734016||CTLA4 Antibody 25 Immune Checkpoint Inhibitor 155||Yervoy (ipilimumab) is an antibody that binds to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), causing increased T-cell activation (PMID: 28891423). Yervoy (ipilimumab) is FDA approved for use in patients with metastatic melanoma, including patients 12 years or older, and in combination with Opdivo (nivolumab) for intermediate or poor-risk renal cell carcinoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (including patients 12 years or older), hepatocellular carcinoma previously treated with Nexavar (sorafenib), in combination with Opdivo (nivolumab) as first-line therapy in patients with PD-L1-positive (>=1%) metastatic non-small cell lung cancer without EGFR or ALK alterations, and in combination with Opdivo (nivolumab) and platinum-based chemotherapy as first-line therapy in patients with metastatic or recurrent non-small cell lung cancer without EGFR or ALK alterations (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03525795||Phase Ib/II||CPI-1205 + Ipilimumab||ORIOn-E: A Study Evaluating CPI-1205 in Patients With Advanced Solid Tumors||Completed||USA||0|