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Drug Name zandelisib
Trade Name
Synonyms ME401|PWT-143|PWT143|ME-401
Drug Descriptions

Zandelisib (ME-401) is a selective Pi3kd inhibitor that inhibits PI3K/AKT pathway signaling to decrease cell proliferation and induce cell death (PMID: 31506873).

DrugClasses PIK3CD inhibitor 25
CAS Registry Number 1595129-71-7
NCIT ID C123925

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + Vincristine Sulfate + zandelisib Cyclophosphamide Doxorubicin Prednisone Rituximab Vincristine Sulfate zandelisib 0 1
Rituximab + zandelisib Rituximab zandelisib 0 2
zandelisib zandelisib 0 2


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