Drug Detail


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Drug Name I-BET151
Trade Name
Synonyms GSK1210151A
Drug Descriptions

I-BET151 is a small molecule that blocks Brd3/4 binding to chromatin, resulting in transcription inhibition and potentially leading to tumor cell death (PMID: 21964340, PMID: 30906568, PMID: 32603665).

DrugClasses BRD3 Inhibitor 2 BRD4 Inhibitor 10
CAS Registry Number 1300031-49-5


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Givinostat + I-BET151 Givinostat I-BET151 0 0
I-BET151 I-BET151 1 0
I-BET151 + Panobinostat I-BET151 Panobinostat 0 0
I-BET151 + Prednisolone I-BET151 Prednisolone 0 0
I-BET151 + SGC0946 I-BET151 SGC0946 1 0
I-BET151 + Trametinib I-BET151 Trametinib 1 0

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