Drug Detail


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Drug Name Divalproex sodium
Trade Name Depakote
Synonyms Valproate semisodium|Sodium divalproex
Drug Descriptions

Depakote (Divalproex sodium) comprises a 1:1 mixture of valproic acid and sodium valproate, which acts as an HDAC inhibitor, potentially resulting in decreased growth and increased apoptosis of tumor cells in combination with other agents (PMID: 25449787, PMID: 20200483). Depakote (divalproex sodium) is FDA approved for treatment of manic episodes associated with bipolar disorder, as well as seizures, and migraines (FDA.gov).

DrugClasses HDAC Inhibitor 45
CAS Registry Number 76584-70-8
NCIT ID C28996


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cetuximab + Divalproex sodium + Panitumumab Cetuximab Divalproex sodium Panitumumab 0 0
Divalproex sodium Divalproex sodium 0 0
Divalproex sodium + Neratinib Divalproex sodium Neratinib 0 1

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