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|Drug Name||Divalproex sodium|
|Synonyms||Valproate semisodium|Sodium divalproex|
Depakote (Divalproex sodium) comprises a 1:1 mixture of valproic acid and sodium valproate, which acts as an HDAC inhibitor, potentially resulting in decreased growth and increased apoptosis of tumor cells in combination with other agents (PMID: 25449787, PMID: 20200483). Depakote (divalproex sodium) is FDA approved for treatment of manic episodes associated with bipolar disorder, as well as seizures, and migraines (FDA.gov).
|DrugClasses||HDAC Inhibitor 38|
|CAS Registry Number||76584-70-8|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Divalproex sodium||Divalproex sodium||0||0|
|Divalproex sodium + Neratinib||Divalproex sodium Neratinib||0||1|