Drug Detail


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Drug Name MKC-3946
Trade Name
Synonyms MKC 3946|MKC3946
Drug Descriptions

MKC-3946 is small molecule drug that targets the endoribonuclease domain of Ire1 alpha (ERN1) and inhibits XBP1 splicing, potentially resulting in increased apoptosis and decreased tumor growth (PMID: 22538852).

CAS Registry Number 1093119-54-0


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Therapy Name Drugs Efficacy Evidence Clinical Trials
BMI-135 + MKC-3946 BMI-135 MKC-3946 0 0
Bortezomib + MKC-3946 Bortezomib MKC-3946 0 0
MKC-3946 MKC-3946 0 0
MKC-3946 + Tanespimycin MKC-3946 Tanespimycin 0 0

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