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|Therapy Name||Bortezomib + Dexamethasone + Lenalidomide + TAK-079|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Bortezomib||Velcade||Velcade (bortezomib) is a reversible proteasome inhibitor that inhibits survival of malignant cells and regulates bone remodeling (PMID: 26579531). Velcade (bortezomib) is FDA approved for the treatment of mantle cell lymphoma and multiple myeloma (FDA.gov).|
|Lenalidomide||Revlimid||IMiD-1||Revlimid (lenalidomide) is a thalidomide analog which regulates cytokine production and stimulates T cells and NK cells activity (PMID: 24328678). Revlimid (lenalidomide) is FDA approved for use in multiple myeloma, relapsed or refractory Mantle cell lymphoma, and in combination with a rituximab product in follicular lymphoma and marginal zone lymphoma (FDA.gov).|
|TAK-079||TAK079|TAK 079|Mezagitamab||CD38 Antibody 9||TAK-079 (Mezagitamab) is a monoclonal antibody that targets CD38, which has potential cytolytic effects against CD38-expressing cells (J Immunol May 1, 2017, 198 (1 Supplement) 224.20, PMID: 32045493).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03984097||Phase I||Dexamethasone + Lenalidomide + TAK-079 Bortezomib + Dexamethasone + Lenalidomide + TAK-079||A Study to Evaluate Subcutaneous TAK-079 Added to Standard of Care Regimens in Participants With Newly Diagnosed Multiple Myeloma (NDMM)||Active, not recruiting||USA||0|