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Drug Name BC2059
Trade Name
Synonyms BC-2059|BC 2059|Tegatrabetan|Tegavivint
Drug Descriptions

Tegavivint (BC2059) binds to beta-catenin (CTNNB1) and interferes with binding to TBL1 and TBLR1, resulting in increased degradation of beta-catenin and potentially leading to increased apoptosis of tumor cells with activated canonical Wnt signaling (PMID: 28500235, PMID: 30793158).

DrugClasses CTNNB1 Inhibitor 27
CAS Registry Number 1227637-23-1
NCIT ID C155885

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Therapy Name Drugs Efficacy Evidence Clinical Trials
BC2059 BC2059 0 4
BC2059 + Bortezomib BC2059 Bortezomib 0 0
BC2059 + Decitabine BC2059 Decitabine 0 1
BC2059 + Osimertinib BC2059 Osimertinib 0 1
BC2059 + Pembrolizumab BC2059 Pembrolizumab 0 1


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