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Drug Name AO-176
Trade Name
Synonyms AO176|AO 176
Drug Descriptions

AO-176 is an antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells and may also stimulate cytotoxic T-cells (PMID: 29873856, PMID: 31879362).

DrugClasses CD47 Antibody 30 Immune Checkpoint Inhibitor 147
CAS Registry Number NA
NCIT ID C159600


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AO-176 AO-176 0 2
AO-176 + Bortezomib + Dexamethasone AO-176 Bortezomib Dexamethasone 0 1
AO-176 + Dexamethasone AO-176 Dexamethasone 0 1

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