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Drug Name Ziftomenib
Trade Name
Synonyms KO539|KO 539|KO-539
Drug Descriptions

Ziftomenib is a small molecule inhibitor of MEN1 (menin)-KMT2A (MLL1) complex, which may lead to decreased growth KMT2A (MLL1)-positive tumor cells, and inhibition of tumor growth (PMID: 36151141).

DrugClasses MEN1-KMT2A Inhibitor 7
CAS Registry Number 2134675-36-6
NCIT ID C164227

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abemaciclib + Ziftomenib Abemaciclib Ziftomenib 0 0
Azacitidine + Venetoclax + Ziftomenib Azacitidine Venetoclax Ziftomenib 0 2
Birabresib + Ziftomenib Birabresib Ziftomenib 0 0
Cytarabine + Daunorubicin + Ziftomenib Cytarabine Daunorubicin Ziftomenib 0 1
Cytarabine + Filgrastim + Fludarabine + Idarubicin + Ziftomenib Cytarabine Filgrastim Fludarabine Idarubicin Ziftomenib 0 1
Cytarabine + Ziftomenib Cytarabine Ziftomenib 0 1
Gilteritinib + Ziftomenib Gilteritinib Ziftomenib 0 1
Pomalidomide + Ziftomenib Pomalidomide Ziftomenib 0 0
Venetoclax + Ziftomenib Venetoclax Ziftomenib 0 1
Ziftomenib Ziftomenib 0 3


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