Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Momelotinib
Trade Name
Synonyms CYT387|CYT-387|GS-0387
Drug Descriptions

Momelotinib (CYT387) is an ATP-competitive and selective inhibitor of JAK1 and JAK2, which inhibits cell proliferation and promotes apoptosis (PMID: 19295546, PMID: 31733040, PMID: 32394008).

DrugClasses JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15
CAS Registry Number 1056634-68-4
NCIT ID C88311


  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")


  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Erlotinib + Momelotinib Erlotinib Momelotinib 0 1
Gilteritinib + Momelotinib Gilteritinib Momelotinib 0 1
Momelotinib Momelotinib 17 6
Momelotinib + Trametinib Momelotinib Trametinib 0 1

Additional content available in CKB BOOST