Drug Detail


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Drug Name Momelotinib
Trade Name
Synonyms CYT387|CYT-387|GS-0387
Drug Descriptions

Momelotinib (CYT387) is an ATP-competitive and selective inhibitor of JAK1 and JAK2, which inhibits cell proliferation and promotes apoptosis (PMID: 19295546, PMID: 31733040, PMID: 32394008).

DrugClasses JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15
CAS Registry Number 1056634-68-4
NCIT ID C88311


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Erlotinib + Momelotinib Erlotinib Momelotinib 0 1
Momelotinib Momelotinib 17 6
Momelotinib + Trametinib Momelotinib Trametinib 0 1

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