Drug Detail


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Drug Name CUDC-907
Trade Name
Synonyms Fimepinostat
Drug Descriptions

CUDC-907 (fimepinostat) is a dual PI3K and HDAC inhibitor, which prevents activation of the PI3K-AKT-mTOR signal transduction pathway, inhibits tumor cell growth, and promotes apoptosis in cancer cells (PMID: 22693356, PMID: 32459381).

DrugClasses HDAC Inhibitor 45 PI3K Inhibitor (Pan) 40
CAS Registry Number 1339928-25-4
NCIT ID C104008


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Therapy Name Drugs Efficacy Evidence Clinical Trials
AZD1480 + CUDC-907 AZD1480 CUDC-907 1 0
Bendamustine + CUDC-907 + Rituximab Bendamustine CUDC-907 Rituximab 0 1
CUDC-907 CUDC-907 5 6
CUDC-907 + Gilteritinib CUDC-907 Gilteritinib 1 0
CUDC-907 + Rituximab CUDC-907 Rituximab 0 1
CUDC-907 + Venetoclax CUDC-907 Venetoclax 0 1

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