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AZD1480 is an ATP-competitive inhibitor of JAK1 and JAK2, which reduces STAT3 activation, potentially resulting in decreased tumor growth (PMID: 22027691, PMID: 24158701) and has been also shown to inhibit ALK, LTK, FGFR1-3, RET and TRKA-C kinases (PMID: 29312610).
|DrugClasses||JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15|
|CAS Registry Number||935666-88-9|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|AZD1480 + CUDC-907||AZD1480 CUDC-907||1||0|