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Drug Name MI-3454
Trade Name
Synonyms MI 3454|MI3454
Drug Descriptions

MI-3454 binds to Menin (MEN1) and inhibits its interaction with KMT2A (MLL), potentially leading to decreased growth of tumor cells harboring KMT2A (MLL) or NUP98 rearrangements or NPM1 mutations, and inhibition of tumor growth (PMID: 31855575, PMID: 38890447).

DrugClasses MEN1-KMT2A Inhibitor 8
CAS Registry Number 2134169-43-8
NCIT ID NA

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Gilteritinib + MI-3454 Gilteritinib MI-3454 0 0
MI-3454 MI-3454 0 0
MI-3454 + Palbociclib MI-3454 Palbociclib 0 0


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