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CC-90009 binds to the ubiquitin E3 ligase complex member cereblon (CRBN), which may lead to increased ubiquitination and proteosomal degradation of substrate proteins, including proteins involved in immune system activity or cell proliferation (PMID: 29788898).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Azacitidine + CC-90009 + Venetoclax||Azacitidine CC-90009 Venetoclax||0||1|
|CC-90009 + Gilteritinib||CC-90009 Gilteritinib||0||1|