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|Therapy Name||Alectinib + Octreotide|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Alectinib||Alecensa||CH5424802|RO5424802||ALK Inhibitor 29 RET Inhibitor 48||Alecensa (alectinib) is an inhibitor of RET and ALK, including ALK fusions and the gatekeeper mutation, L1196M (PMID: 21575866, PMID: 25349307). Alecensa (alectinib) is FDA-approved for use in patients with ALK-positive (rearrangements and fusions) non-small cell lung cancer (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|ALK R1192P||malignant pheochromocytoma||no benefit||Alectinib + Octreotide||Case Reports/Case Series||Actionable||In a clinical case study, addition of Alecensa (alectinib) to Octreotide treatment did not lead to a response in a patient with malignant pheochromocytoma harboring ALK R1192P, with a radiological stable disease after 1 month of treatment and disease progression after 5 months of treatment (PMID: 34371380).||34371380|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|