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Drug Name TAK-659
Trade Name
Synonyms
Drug Descriptions

TAK-659 is an inhibitor of spleen tyrosine kinase (SYK), which may lead to B-cell inhibition and antitumor activity (http://meetinglibrary.asco.org/content/134551-144).

DrugClasses SYK Inhibitor 13

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bendamustine + Rituximab + TAK-659 Bendamustine Rituximab TAK-659 0 1
Bendamustine + TAK-659 Bendamustine TAK-659 0 1
Cyclophosphamide + Doxorubicin + Prednisone + Rituximab + TAK-659 + Vincristine Cyclophosphamide Doxorubicin Prednisone Rituximab TAK-659 Vincristine 0 1
Gemcitabine + TAK-659 Gemcitabine TAK-659 0 1
Ibrutinib + TAK-659 Ibrutinib TAK-659 0 1
Ixazomib + TAK-659 Ixazomib TAK-659 0 1
Lenalidomide + TAK-659 Lenalidomide TAK-659 0 1
MLN1117 + TAK-659 MLN1117 TAK-659 0 0
Nivolumab + TAK-659 Nivolumab TAK-659 0 1
NKTR-214 + TAK-659 NKTR-214 TAK-659 0 1
Paclitaxel + TAK-659 Paclitaxel TAK-659 0 1
TAK-659 TAK-659 0 5
TAK-659 + Venetoclax TAK-659 Venetoclax 0 1


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