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Drug Name MLN1117
Trade Name
Synonyms INK1117|TAK-117|Serabelisib|MLN-1117
Drug Descriptions

Serabelisib (MLN1117) selectively inhibits PI3K alpha kinase, including mutations of PIK3CA, and therefore, targets the PI3K/Akt/mTOR pathway with potentially less toxicity than pan-PI3K inhibitors (PMID: 28490463, PMID: 30168905).

DrugClasses PIK3CA inhibitor 16

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Mivavotinib + MLN1117 MLN1117 Mivavotinib 0 0
MLN1117 MLN1117 5 2
MLN1117 + Paclitaxel + Sapanisertib MLN1117 Paclitaxel Sapanisertib 0 1
MLN1117 + Sapanisertib MLN1117 Sapanisertib 1 4


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