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|Therapy Name||AR-42 + Decitabine|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|AR-42||HDAC42||HDAC Inhibitor 38||AR-42 is a histone deacetylase (HDAC) inhibitor, which may lead to increased apoptosis of tumor cells and decreased tumor growth (PMID: 23178755, PMID: 21778190, PMID: 32037935).|
|Decitabine||Dacogen||5-aza-2-deoxycytidine||DNMT inhibitor (Pan) 5||Dacogen (decitabine) is cytidine analog that incorporates into DNA and forms covalent bonds with DNA methyltransferases (DNMTs), resulting in decreased DNMT activity and hypomethylation, and potentially leading to reduced tumor growth (PMID: 28159832, PMID: 25130173). Dacogen (decitabine) is FDA approved for use in patients with myelodysplastic syndromes (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Unknown unknown||acute myeloid leukemia||no benefit||AR-42 + Decitabine||Phase I||Actionable||In a Phase I trial, AR-42 and Dacogen (decitabine) combination treatment in patients with acute myeloid leukemia resulted in an overall response rate of 23.1% (3/13), including one patient with complete remission and two patients with complete remission with incomplete count recovery, but the trial did not meet its biological endpoint for safety and dosing (PMID: 32037935; NCT01798901).||32037935|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT01798901||Phase I||AR-42 + Decitabine||AR-42 and Decitabine in Treating Patients With Acute Myeloid Leukemia||Completed|