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Drug Name Omacetaxine mepesuccinate
Trade Name Synribo
Synonyms homoharringtonine|CGX-635
Drug Descriptions

Synribo (omacetaxine mepesuccinate) is a semisynthetic alkaloid that inhibits protein synthesis, resulting in increased apoptosis and cell-cycle arrest in tumor cells (PMID: 26935769, PMID: 24516334). Synribo (omacetaxine mepesuccinate) is FDA approved for use in patients with chronic myeloid leukemia (FDA.gov).

DrugClasses
CAS Registry Number 26833-87-4
NCIT ID C1127

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Abivertinib + Omacetaxine mepesuccinate Abivertinib Omacetaxine mepesuccinate 1 0
Cytarabine + Decitabine + Omacetaxine mepesuccinate Cytarabine Decitabine Omacetaxine mepesuccinate 0 1
Decitabine + Omacetaxine mepesuccinate Decitabine Omacetaxine mepesuccinate 0 1
Omacetaxine mepesuccinate Omacetaxine mepesuccinate 0 0
Omacetaxine mepesuccinate + Venetoclax Omacetaxine mepesuccinate Venetoclax 0 2


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