Drug Detail


Missing content? – Request curation!

Request curation for specific Genes, variants, or PubMed publications.

Have questions, comments or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Drug Name Omacetaxine mepesuccinate
Trade Name Synribo
Synonyms homoharringtonine|CGX-635
Drug Descriptions

Synribo (omacetaxine mepesuccinate) is a semisynthetic alkaloid that inhibits protein synthesis, resulting in increased apoptosis and cell-cycle arrest in tumor cells (PMID: 26935769, PMID: 24516334). Synribo (omacetaxine mepesuccinate) is FDA approved for use in patients with chronic myeloid leukemia (FDA.gov).

CAS Registry Number 26833-87-4


  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"


  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Therapy Name Drugs Efficacy Evidence Clinical Trials
Abivertinib + Omacetaxine mepesuccinate Abivertinib Omacetaxine mepesuccinate 1 0
Cytarabine + Decitabine + Omacetaxine mepesuccinate Cytarabine Decitabine Omacetaxine mepesuccinate 0 1
Decitabine + Omacetaxine mepesuccinate Decitabine Omacetaxine mepesuccinate 0 1
Omacetaxine mepesuccinate Omacetaxine mepesuccinate 0 0
Omacetaxine mepesuccinate + Venetoclax Omacetaxine mepesuccinate Venetoclax 0 2

Additional content available in CKB BOOST