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|Therapy Name||Abivertinib + Omacetaxine mepesuccinate|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Abivertinib||Avitinib|AC0010|AC0010MA||BTK inhibitor 34 EGFR Inhibitor 3rd gen 25||Abivertinib (AC0010) is a BTK inhibitor and a third-generation EGFR inhibitor that blocks the activity of mutant forms of EGFR while sparing wild-type EGFR, which potentially results in increased apoptosis and cell cycle arrest, and decreased viability and colony formation, and inhibits tumor growth (PMID: 27573423, PMID: 31310800).|
|Omacetaxine mepesuccinate||Synribo||homoharringtonine|CGX-635||Synribo (omacetaxine mepesuccinate) is a semisynthetic alkaloid that inhibits protein synthesis, resulting in increased apoptosis and cell-cycle arrest in tumor cells (PMID: 26935769, PMID: 24516334). Synribo (omacetaxine mepesuccinate) is FDA approved for use in patients with chronic myeloid leukemia (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FLT3 exon 14 ins||acute myeloid leukemia||sensitive||Abivertinib + Omacetaxine mepesuccinate||Preclinical - Patient cell culture||Actionable||In a preclinical study, treatment with the combination of Abivertinib (AC0010) and Synribo (omacetaxine mepesuccinate) resulted in increased apoptosis and reduced viability of acute myeloid leukemia (AML) cell lines harboring FLT3-ITD mutations and decreased viability of patient-derived AML cells harboring FLT3-ITD mutations in culture, and reduced tumor burden and increased survival in cell line xenograft models compared to either agent alone (PMID: 31310800).||31310800|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|