Drug Detail


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Drug Name MB-102
Trade Name
Synonyms CD123CAR-CD28-CD3zeta-EGFRt-expressing T lymphocytes|CD123 CAR-T
Drug Descriptions

MB-102 is comprised of engineered T cells expressing chimeric antigen receptor consisting of CD123, CD28 fused to CD3 zeta, and a truncated EGFR (EGFRt), which may induce cytotoxic immune response against CD123-positive tumor cells (NCI Drug Dictionary).

CAS Registry Number NA
NCIT ID C165435


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclophosphamide + Decitabine + Fludarabine + MB-102 Cyclophosphamide Decitabine Fludarabine MB-102 0 1
Cyclophosphamide + Fludarabine + MB-102 + Mesna + Rituximab Cyclophosphamide Fludarabine MB-102 Mesna Rituximab 0 1
MB-102 MB-102 0 0

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