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|Synonyms||CD123CAR-CD28-CD3zeta-EGFRt-expressing T lymphocytes|CD123 CAR-T|
MB-102 is comprised of engineered T cells expressing chimeric antigen receptor consisting of CD123, CD28 fused to CD3 zeta, and a truncated EGFR (EGFRt), which may induce cytotoxic immune response against CD123-positive tumor cells (NCI Drug Dictionary).
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Cyclophosphamide + Decitabine + Fludarabine + MB-102||Cyclophosphamide Decitabine Fludarabine MB-102||0||1|
|Cyclophosphamide + Fludarabine + MB-102 + Mesna + Rituximab||Cyclophosphamide Fludarabine MB-102 Mesna Rituximab||0||1|