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|Therapy Name||Decitabine + Eltrombopag|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Decitabine||Dacogen||5-aza-2-deoxycytidine||DNMT inhibitor (Pan) 5||Dacogen (decitabine) is cytidine analog that incorporates into DNA and forms covalent bonds with DNA methyltransferases (DNMTs), resulting in decreased DNMT activity and hypomethylation, and potentially leading to reduced tumor growth (PMID: 28159832, PMID: 25130173). Dacogen (decitabine) is FDA approved for use in patients with myelodysplastic syndromes (FDA.gov).|
|Eltrombopag||Promacta||Eltrombopag is a thromobopoeitin receptor agonist that causes increased proliferation and differentiation of megakaryocytic cells and increased platelet production (NCI Drug Dictionary).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status|
|NCT02010645||Phase II||Decitabine + Eltrombopag||Eltrombopag With Decitabine in Advanced Myelodysplastic Syndrome (MDS)||Terminated|