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|Therapy Name||Decitabine + Talacotuzumab|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Decitabine||Dacogen||5-aza-2-deoxycytidine||DNMT inhibitor (Pan) 5||Dacogen (decitabine) is cytidine analog that incorporates into DNA and forms covalent bonds with DNA methyltransferases (DNMTs), resulting in decreased DNMT activity and hypomethylation, and potentially leading to reduced tumor growth (PMID: 28159832, PMID: 25130173). Dacogen (decitabine) is FDA approved for use in patients with myelodysplastic syndromes (FDA.gov).|
|Talacotuzumab||JNJ-56022473|CSL362|JNJ-473||Talacotuzumab (JNJ-56022473) is a monoclonal antibody directed against CD123 (IL3RA), which may increase antibody-dependent cell-mediated cytoxicity of CD123 (IL3RA)-expressing tumor cells (Blood Dec 2015, 126 (23) 4946).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT02472145||Phase III||Decitabine Decitabine + Talacotuzumab||An Efficacy and Safety Study of Decitabine (DACOGEN) Plus Talacotuzumab (JNJ-56022473; Anti CD123) Versus Decitabine (DACOGEN) Alone in Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy||Completed||USA | FRA | ESP | DEU | BEL||9|