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|Therapy Name||Decitabine + TK216|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Decitabine||Dacogen||5-aza-2-deoxycytidine||DNMT inhibitor (Pan) 5||Dacogen (decitabine) is cytidine analog that incorporates into DNA and forms covalent bonds with DNA methyltransferases (DNMTs), resulting in decreased DNMT activity and hypomethylation, and potentially leading to reduced tumor growth (PMID: 28159832, PMID: 25130173). Dacogen (decitabine) is FDA approved for use in patients with myelodysplastic syndromes (FDA.gov).|
|TK216||TK-216|TK 216||TK216 binds to and inhibits Ets-family transcription factor, which may lead to anti-tumor effects (PMID: 31182435).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT03752138||Phase I||Decitabine + TK216 TK216||TK216 and Decitabine in Treating Patients With Relapsed and Refractory Acute Myeloid Leukemia||Withdrawn||0|