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Drug Name | Milademetan Tosylate |
Trade Name | |
Synonyms | DS-3032b |
Drug Descriptions |
Milademetan Tosylate (DS-3032b) binds to MDM2 and prevents binding to p53, resulting in activation of p53 signaling and increased tumor cell apoptosis (PMID: 29416773, PMID: 32651541). |
DrugClasses | MDM2 Inhibitor 20 |
CAS Registry Number | 1398569-75-9 |
NCIT ID | C107384 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cytarabine + Milademetan Tosylate | Cytarabine Milademetan Tosylate | 0 | 1 |
Cytarabine + Milademetan Tosylate + Venetoclax | Cytarabine Milademetan Tosylate Venetoclax | 0 | 1 |
Milademetan Tosylate | Milademetan Tosylate | 2 | 4 |
Milademetan Tosylate + Quizartinib | Milademetan Tosylate Quizartinib | 0 | 1 |