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Drug Name Milademetan
Trade Name
Synonyms DS-3032b|Milademetan Tosylate|DS3032b|DS 3032b|RAIN-32
Drug Descriptions

Milademetan binds to MDM2 and prevents binding to p53, resulting in activation of p53 signaling and increased tumor cell apoptosis (PMID: 29416773, PMID: 32651541).

DrugClasses MDM2 Inhibitor 22
CAS Registry Number 1398569-75-9
NCIT ID C107384


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cytarabine + Milademetan Cytarabine Milademetan 0 1
Cytarabine + Milademetan + Venetoclax Cytarabine Milademetan Venetoclax 0 1
Fulvestrant + Milademetan Fulvestrant Milademetan 0 1
Milademetan Milademetan 0 5
Milademetan + Quizartinib Milademetan Quizartinib 0 1
Milademetan + Trametinib Milademetan Trametinib 0 0

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