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Drug Name Pinometostat
Trade Name
Synonyms EPZ-5676|EPZ5676
Drug Descriptions

Pinometostat (EPZ-5676) inhibits DOT1L histone methyltransferase activity, resulting in decreased growth of leukemia cells with MLL rearrangements (PMID: 23801631, PMID: 26645404, PMID: 29724899).

DrugClasses DOT1L Inhibitor 3
CAS Registry Number 1380288-87-8
NCIT ID C103179

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Pinometostat Azacitidine Pinometostat 0 1
Cytarabine + Daunorubicin + Pinometostat Cytarabine Daunorubicin Pinometostat 0 1
Pinometostat Pinometostat 2 1


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