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Drug Name AMG 397
Trade Name
Synonyms AMG-397|AMG397|Murizatoclax
Drug Descriptions

AMG 397 is a small molecule inhibitor of MCL1 that selectively disrupts the interaction with members of the Bcl2 family, potentially resulting in increased cellular apoptosis, decreased cell viability, and reduced tumor growth (Cancer Res 2020;80(16 Suppl):Abstract nr 6218).

DrugClasses MCL1 Inhibitor 18
CAS Registry Number 2245848-05-7
NCIT ID C156740

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Therapy Name Drugs Efficacy Evidence Clinical Trials
AMG 397 AMG 397 0 1
AMG 397 + Azacitidine AMG 397 Azacitidine 0 1
AMG 397 + Dexamethasone AMG 397 Dexamethasone 0 1
AMG 397 + Venetoclax AMG 397 Venetoclax 0 0


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