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Drug Name Olutasidenib
Trade Name
Synonyms FT-2102
Drug Descriptions

Olutasidenib (FT-2102) specifically targets IDH1 with mutations at amino acid R132, which results in decreased 2HG production and potentially leads to increased differentiation and decreased proliferation of IDH R132-mutant cancer cells (PMID: 31971798).

DrugClasses IDH1 Inhibitor 8

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ASTX727 + Olutasidenib Olutasidenib decitabine and cedazuridine 0 1
Azacitidine + Olutasidenib Azacitidine Olutasidenib 0 2
Cisplatin + Gemcitabine + Olutasidenib Cisplatin Gemcitabine Olutasidenib 0 1
Cytarabine + Olutasidenib Cytarabine Olutasidenib 0 1
Nivolumab + Olutasidenib Nivolumab Olutasidenib 0 1
Olutasidenib Olutasidenib 0 2


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