Drug Detail


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Drug Name Olutasidenib
Trade Name Rezlidhia
Synonyms FT-2102
Drug Descriptions

Rezlidhia (olutasidenib) targets IDH1 R132 mutations, leading to decreased 2HG production and potentially promoting differentiation and decreasing proliferation of IDH R132-mutant cancer cells (PMID: 31971798). Rezlidhia (olutasidenib) is FDA approved for use in adult patients with relapsed or refractory acute myeloid leukemia with a susceptible IDH1 mutation (FDA.gov).

DrugClasses IDH1 Inhibitor 8
CAS Registry Number 1887014-12-1
NCIT ID C129687


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Azacitidine + Olutasidenib Azacitidine Olutasidenib 0 2
Cisplatin + Gemcitabine + Olutasidenib Cisplatin Gemcitabine Olutasidenib 0 1
Cytarabine + Olutasidenib Cytarabine Olutasidenib 0 1
Decitabine and Cedazuridine + Olutasidenib Decitabine and Cedazuridine Olutasidenib 0 1
Nivolumab + Olutasidenib Nivolumab Olutasidenib 0 1
Olutasidenib Olutasidenib 10 2
Olutasidenib + Temozolomide Olutasidenib Temozolomide 0 1

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