Drug Detail


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Drug Name NP137
Trade Name
Synonyms NP 137|NP-137
Drug Descriptions

NP137 is a humanized monoclonal antibody against netrin-1, which blocks netrin-1 binding to its receptors, potentially leads to dependence receptor (DR)-induced apoptosis (Cancer Res 2015;75(15 Suppl):Abstract nr 2921).

CAS Registry Number NA
NCIT ID C179293


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Atezolizumab + Bevacizumab + NP137 Atezolizumab Bevacizumab NP137 0 1
Azacitidine + NP137 + Venetoclax Azacitidine NP137 Venetoclax 0 1
Carboplatin + NP137 + Paclitaxel Carboplatin NP137 Paclitaxel 0 1
Carboplatin + NP137 + Paclitaxel Trevatide + Pembrolizumab Carboplatin NP137 Paclitaxel Trevatide Pembrolizumab 0 1
Fluorouracil + Irinotecan + Leucovorin + NP137 + Oxaliplatin Fluorouracil Irinotecan Leucovorin NP137 Oxaliplatin 0 2
NP137 NP137 0 2
NP137 + Pembrolizumab NP137 Pembrolizumab 0 1
NP137 + unspecified PD-1 antibody NP137 unspecified PD-1 antibody 0 1
NP137 + unspecified PD-L1 antibody NP137 unspecified PD-L1 antibody 0 1

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