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Drug Name Paclitaxel Trevatide
Trade Name
Synonyms ANG1005|GRN1005
Drug Descriptions

Paclitaxel Trevatide (GRN1005) consists of paclitaxel bound to a peptide that binds LRP-1, which allows the drug-peptide conjugate to cross the blood-brain barrier and delivers paclitaxel to LRP-1 expressing tumor cells (PMID: 22203732, PMID: 23349317).

DrugClasses Chemotherapy - Taxane 2
CAS Registry Number 1075214-55-9
NCIT ID C99461

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Carboplatin + NP137 + Paclitaxel Trevatide + Pembrolizumab Carboplatin NP137 Paclitaxel Trevatide Pembrolizumab 0 1
Carboplatin + Paclitaxel Trevatide + trastuzumab and hyaluronidase-oysk injection Carboplatin Paclitaxel Trevatide trastuzumab and hyaluronidase-oysk injection 0 1
Paclitaxel Trevatide Paclitaxel Trevatide 0 2


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