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|Therapy Name||Osimertinib + Quaratusugene Ozeplasmid|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|Osimertinib||Tagrisso||AZD9291||EGFR Inhibitor 3rd gen 21||Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EFGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EFGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).|
|Quaratusugene Ozeplasmid||GPX-001|DOTAP:cholesterol-Fus1 liposome complex|INGN 401|DOTAP:chol-Fus1||Quaratusugene Ozeplasmid is a complex of liposomal nanoparticles with a plasmid expression cassette encoding the human FUS1 protein, which may lead to induction of tumor cell apoptosis and suppression of tumor cell proliferation (PMID: 15486560).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04486833||Phase Ib/II||Osimertinib + Quaratusugene Ozeplasmid Osimertinib||TUSC2-nanoparticles (GPX-001) and Osimertinib in Patients With Stage IV Lung Cancer Who Progressed on Osimertinib Alone (Acclaim-1)||Recruiting||USA||0|