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|Therapy Name||LY3295668 + Osimertinib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|LY3295668||LY3295668 erbumine|AK-01||Aurka Inhibitors 25||LY3295668 selectively inhibits Aurora A kinase (AURA), which results in apoptosis, inhibition of cell proliferation, and tumor growth inhibition (PMID: 31530649).|
|Osimertinib||Tagrisso||AZD9291||EGFR Inhibitor 3rd gen 25||Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT05017025||Phase Ib/II||LY3295668 + Osimertinib||Aurora Kinase Inhibitor LY3295668 in Combination With Osimertinib for the Treatment of Advanced or Metastatic EGFR-Mutant Non-squamous Non-small Cell Lung Cancer||Recruiting||USA||0|