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|Therapy Name||BLU-945 + Osimertinib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|BLU-945||BLU 945|BLU945||EGFR Inhibitor 4th gen 13||BLU-945 is a wild-type-sparing 4th generation EGFR inhibitor with activity against EGFR T790M and EGFR C797S, which may block EGFR signaling and lead to tumor growth inhibition (PMID: 35838760).|
|Osimertinib||Tagrisso||AZD9291||EGFR Inhibitor 3rd gen 26||Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04862780||Phase Ib/II||BLU-945 BLU-945 + Osimertinib||(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC||Recruiting||USA | GBR | FRA | ESP | CAN||6|