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|Therapy Name||MRX-2843 + Osimertinib|
|Drug Name||Trade Name||Synonyms||Drug Classes||Drug Description|
|MRX-2843||MRX2843|MRX 2843||FLT3 Inhibitor 61 MERTK Inhibitor 13 TYRO3 Inhibitor 8||MRX-2843 is a small molecule inhibitor of MERTK, FLT3 and TYRO3, resulting in apoptosis and anti-tumor effects (PMID: 27158668, PMID: 30501104).|
|Osimertinib||Tagrisso||AZD9291||EGFR Inhibitor 3rd gen 24||Tagrisso (osimertinib) is a third-generation EGFR inhibitor that selectively binds mutant forms of the EGF receptor, inhibiting downstream signaling and potentially reducing cell proliferation and growth in EGFR overexpressing tumors (PMID: 29151359). Tagrisso (osimertinib) is FDA-approved for use as adjuvant therapy after resection in patients with non-small cell lung cancer (NSCLC) harboring EGFR exon 19 deletion or L858R, as first-line therapy in patients with metastatic NSCLC harboring EGFR exon 19 deletion or L858R, and for treatment in patients with metastatic NSCLC harboring EGFR T790M whose disease progressed after EGFR TKI therapy (FDA.gov).|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|
|NCT04762199||Phase I||MRX-2843 + Osimertinib||MRX-2843 and Osimertinib for the Treatment of Advanced EGFR Mutant Non-small Cell Lung Cancer||Recruiting||USA||0|