Drug Detail


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Drug Name Mirvetuximab Soravtansine
Trade Name Elahere
Synonyms IMGN853|M9346A-sulfo-SPDB-DM4|mirvetuximab soravtansine-gynx
Drug Descriptions

Elahere (mirvetuximab soravtansine) is an antibody-drug conjugate comprised of an antibody directed against FOLR1 linked to the tubulin polymerization-inhibiting drug DM4, leading to cell death in Folr1-expressing tumors (PMID: 26136852, PMID: 25904506). Elahere (mirvetuximab soravtansine) is FDA approved for use in patients with FOLR1-positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic treatments (FDA.gov).

DrugClasses FOLR1-targeted Therapy 20
CAS Registry Number 1453084-37-1
NCIT ID C102566


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Mirvetuximab Soravtansine Bevacizumab Mirvetuximab Soravtansine 0 2
Carboplatin + Mirvetuximab Soravtansine Carboplatin Mirvetuximab Soravtansine 0 2
Gemcitabine + Mirvetuximab Soravtansine Gemcitabine Mirvetuximab Soravtansine 0 1
Mirvetuximab Soravtansine Mirvetuximab Soravtansine 0 9
Mirvetuximab Soravtansine + Olaparib Mirvetuximab Soravtansine Olaparib 0 1
Mirvetuximab Soravtansine + Pembrolizumab Mirvetuximab Soravtansine Pembrolizumab 0 1
Mirvetuximab Soravtansine + Rucaparib Mirvetuximab Soravtansine Rucaparib 0 1
Mirvetuximab Soravtansine + SL-172154 Mirvetuximab Soravtansine SL-172154 0 1

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