Drug Detail


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Drug Name NLG207
Trade Name
Synonyms IT-101|EP0057|CRLX101
Drug Descriptions

NLG207 (CRLX101) is a nanoparticle conjugated to camptothecin, which inhibits topoisomerase-1 and HIF1-alpha, which may increase sensitivity to chemoradiation, and may result in tumor growth inhibition (PMID: 27784746, PMID: 33390325, PMID: 33632874).

CAS Registry Number 1883668-61-8
NCIT ID C62600


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + NLG207 Bevacizumab NLG207 0 2
Enzalutamide + NLG207 Enzalutamide NLG207 0 1
Fluorouracil + NLG207 + Radiotherapy Fluorouracil NLG207 Radiotherapy 0 0
NLG207 NLG207 0 2
NLG207 + Olaparib NLG207 Olaparib 0 2
NLG207 + Paclitaxel NLG207 Paclitaxel 0 0

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