Therapy Detail

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Therapy Name CRLX101 + Paclitaxel
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CRLX101 IT-101|EP0057 CRLX101 is a nanoparticle conjugated to Camptothecin, which inhibits topoisomerase-1 and HIF1-alpha, and when combined with radiotherapy may result in increased sensitivity (PMID: 27784746, PMID: 33390325).
Paclitaxel Taxol 7-Epipaclitaxel Antimicrotubule Agent 13 BCL2 Family Inhibitor 6 Taxol (paclitaxel) binds to tubulin to inhibit microtubule disassembly, which results in decreased cell division, and also binds to the anti-apoptotic factor Bcl-2, promoting apoptosis (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
Unknown unknown ovary epithelial cancer not applicable CRLX101 + Paclitaxel Phase Ib/II Actionable In a Phase Ib/II trial, CRLX101 in combination with weekly Taxol (paclitaxel) resulted in an objective response rate (ORR) of 31.6% (6/19, 1 complete response, 5 partial responses) and a median progression-free survival of 5.4 months in patients with recurrent or persistent epithelial ovarian, fallopian tube, or primary peritoneal cancer, although the ORR was not superior to that of historical control (PMID: 33390325; NCT02389985). 33390325
Unknown unknown fallopian tube cancer not applicable CRLX101 + Paclitaxel Phase Ib/II Actionable In a Phase Ib/II trial, CRLX101 in combination with weekly Taxol (paclitaxel) resulted in an objective response rate (ORR) of 31.6% (6/19, 1 complete response, 5 partial responses) and a median progression-free survival of 5.4 months in patients with recurrent or persistent epithelial ovarian, fallopian tube, or primary peritoneal cancer, although the ORR was not superior to that of historical control (PMID: 33390325; NCT02389985). 33390325
Unknown unknown peritoneum cancer not applicable CRLX101 + Paclitaxel Phase Ib/II Actionable In a Phase Ib/II trial, CRLX101 in combination with weekly Taxol (paclitaxel) resulted in an objective response rate (ORR) of 31.6% (6/19, 1 complete response, 5 partial responses) and a median progression-free survival of 5.4 months in patients with recurrent or persistent epithelial ovarian, fallopian tube, or primary peritoneal cancer, although the ORR was not superior to that of historical control (PMID: 33390325; NCT02389985). 33390325

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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries


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