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Drug Name | GSK126 |
Trade Name | |
Synonyms | GSK2816126|GSK-126 |
Drug Descriptions |
GSK126 selectively inhibits EZH2, resulting in decreased H3K27 tri-methylation, and potentially leading to decreased tumor cell proliferation and reduced tumor growth (PMID: 23051747, PMID: 25686104, PMID: 31471312). |
DrugClasses | EZH2 inhibitor 18 |
CAS Registry Number | 1346574-57-9 |
NCIT ID | C113334 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
ACY-957 + GSK126 | ACY-957 GSK126 | 0 | 0 |
GSK126 | GSK126 | 5 | 1 |
GSK126 + Lenalidomide | GSK126 Lenalidomide | 0 | 0 |
GSK126 + Pomalidomide | GSK126 Pomalidomide | 0 | 0 |