Drug Detail


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Drug Name GSK126
Trade Name
Synonyms GSK2816126|GSK-126
Drug Descriptions

GSK126 selectively inhibits EZH2, resulting in decreased H3K27 tri-methylation, and potentially leading to decreased tumor cell proliferation and reduced tumor growth (PMID: 23051747, PMID: 25686104, PMID: 31471312).

DrugClasses EZH2 inhibitor 20
CAS Registry Number 1346574-57-9
NCIT ID C113334


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Therapy Name Drugs Efficacy Evidence Clinical Trials
ACY-957 + GSK126 ACY-957 GSK126 0 0
AZD1390 + GSK126 AZD1390 GSK126 0 0
Dexamethasone + GSK126 Dexamethasone GSK126 0 0
GSK126 GSK126 7 1
GSK126 + KU-60019 GSK126 KU-60019 0 0
GSK126 + Lenalidomide GSK126 Lenalidomide 0 0
GSK126 + Olaparib GSK126 Olaparib 0 0
GSK126 + Pictilisib GSK126 Pictilisib 1 0
GSK126 + Pomalidomide GSK126 Pomalidomide 0 0

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